NCCR

1. Targeted mouse
  • Gene :

    GABAA receptor alpha 5 subunit (Gabra5)

     
  • Line name :

    Alpha5(H105R)

     
  • Organ :

    CNS e.g. hippocampus

     
  • Cell :

    Neurons

     
  • Feature :

    GABAA receptors containing the H105R point mutation in the alpha5 subunit are insensitive to modulation by benzodiazepines such as diazepam. In GABRA5-H101R mice the myorelaxant response to diazepam is reduced. In addition, in drug-free animals, trace fear conditioning is facilitated.

     
  • Contact :

    Uwe Rudolph

     
  • Email :

    rudolphpharma.unizh.ch

     
  • Phone :

    +411 635 5938

     
  • Lab :

    Institute of Pharmacology and Toxicology, University of Zürich

     
  • Ref. :

    Abstract

     
  • Update :

    Tuesday, 15th April 2003 - 12:17

     


All genes


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