NCCR


1. Targeted mouse


2. Targeted mouse
  • Gene :

    Nogo-A

     
  • Line name :

    Nogo-A KO

     
  • Organ :

    CNS

     
  • Cell :

    mainly oligodendrocytes and neurons

     
  • Feature :

    Conventional knockouts of the myelin neurite outgrowth inhibitor Nogo-A
    Back-crossed into the C57Bl/6 and the Sv129 background

     
  • Contact :

    Martin Schwab

     
  • Email :

    schwabhifo.unizh.ch

     
  • Phone :

    +41 44 635 3330

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Wednesday, 6th July 2005 - 12:30

     


3. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


4. Transgenic mouse
  • Gene :

    FcR(gamma)

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav

     
  • Organ :

    Ubiquitous

     
  • Cell :

    macrophages, neutrophils, mast cells, basophils and NK cells

     
  • Feature :

    Fcer1g knockout mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors. The deleted gamma chain subunit is essential for cell surface expression of these molecules.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    eur j immunol (1994) 25(7): 2107-2110.

     
  • Update :

    Monday, 15th November 2004 - 16:36

     


5. Transgenic mouse
  • Gene :

    Rag1

     
  • Line name :

    B6.129S7-Rag1tm1Mom/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    Homozygotes for targeted null mutations are devoid of mature B and T lymphocytes due to an inability to rearrange their immunoglobulin and T cell receptor genes. Mutants show severe combined immunodeficiency and susceptibility to infections.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


6. Transgenic mouse
  • Gene :

    FcR(gamma),IgH

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav x B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    This mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors and they are unable to produce functional Ab's.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


7. Transgenic mouse


8. Transgenic mouse
  • Gene :

    prnp

     
  • Line name :

    Tga19; B6,129Sv-Tga19+/+(phg), PrnpZH1/ZH1

     
  • Organ :

    brain and periphery

     
  • Cell :

    brain and periphery

     
  • Feature :

    Reintroduciton of PrP constructs on prnp knockout background (introduction of half genomic PrP construct (phgPrP) copy number 30)

     
  • Contact :

    Schwarz Petra/ Adrinao Aguzzi

     
  • Email :

    petra.schwarzusz.ch

     
  • Phone :

    +41 44 255 21 51

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    fischer m et al. 1996 embo

     
  • Update :

    Monday, 4th July 2005 - 17:39

     


9. Transgenic mouse
  • Gene :

    prnp gene

     
  • Line name :

    Tga20 B6, 129Sv-Tga20(phg)PrnpZH1/ZH1

     
  • Organ :

    brain and periphery

     
  • Cell :

    brain and periphery

     
  • Feature :

    Reintroduciton of PrP constructs on prnp knockout background (introduction of half genomic PrP construct (phgPrP) copy number 360

     
  • Contact :

    Petra Schwarz/Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 51

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    fischer m et al., 1996 embo

     
  • Update :

    Monday, 4th July 2005 - 17:42

     


10. Transgenic mouse



All genes


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