NCCR

1. Transgenic mouse
  • Gene :

    Inhibitor-1 (PP1 inhibitor)

     
  • Line name :

    I-1*

     
  • Organ :

    Depends on the line of transactivator (tTA or rtTA) used for crossing

     
  • Cell :

    Forebrain neurons when crossed with CaMKIIα promoter-rtTA mice

     
  • Feature :

    TetO promoter fused to a constitutively active protein phosphatase 1 (PP1) inhibitor cDNA.
    Improved learning and memory when expressed in forebrain neurons.

     
  • Contact :

    Isabelle Mansuy

     
  • Email :

    mansuyhifo.unizh.ch

     
  • Phone :

    +41 44 635 3360

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Monday, 23rd July 2007 - 15:28

     


2. Transgenic mouse


3. Transgenic mouse
  • Gene :

    PP2A Calpha mutant L199P

     
  • Line name :

    Dom1

     
  • Organ :

    Brain

     
  • Cell :

    Neurons

     
  • Feature :

    Expression of dominant negative mutant form of the catalytic subunit Calpha of Protein Phosphatase 2A (PP2A), L199P,
    under the control of the mThy1.2 promoter causes reduced PP2A activity and hyperphosphorylation of endogenous tau protein

     
  • Contact :

    Jürgen Götz

     
  • Email :

    goetzbli.unizh.ch

     
  • Phone :

    +411 634 8873

     
  • Lab :

    Division of Psychiatry Research

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:26

     


4. Transgenic mouse


All genes


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