NCCR


1. Transgenic mouse


2. Targeted mouse


3. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


4. Transgenic mouse


5. Transgenic mouse


6. Transgenic mouse
  • Gene :

    IL-12p35

     
  • Line name :

    B6;IL-12p35tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    The p35 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


7. Transgenic mouse
  • Gene :

    IL12p40

     
  • Line name :

    B6;IL-12p40tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    p40 has been shown to be a subunit of another composite cytokine, designated IL23 .
    The p40 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


8. Transgenic mouse
  • Gene :

    Inhibitor-1 (PP1 inhibitor)

     
  • Line name :

    I-1*

     
  • Organ :

    Depends on the line of transactivator (tTA or rtTA) used for crossing

     
  • Cell :

    Forebrain neurons when crossed with CaMKIIα promoter-rtTA mice

     
  • Feature :

    TetO promoter fused to a constitutively active protein phosphatase 1 (PP1) inhibitor cDNA.
    Improved learning and memory when expressed in forebrain neurons.

     
  • Contact :

    Isabelle Mansuy

     
  • Email :

    mansuyhifo.unizh.ch

     
  • Phone :

    +41 44 635 3360

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Monday, 23rd July 2007 - 15:28

     


9. Targeted mouse
  • Gene :

    MAG

     
  • Line name :

    MAG-KO

     
  • Organ :

    Nervous system

     
  • Cell :

    oligodendrocytes and Schwann cells

     
  • Feature :

    Knock-out for the myelin associated glycoprotein (MAG)

     
  • Contact :

    Leda Dimou

     
  • Email :

    dimouhifo.unizh.ch

     
  • Phone :

    +41 44 635 3256

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Wednesday, 6th July 2005 - 12:28

     


10. Transgenic mouse



All genes


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