NCCR


1. Transgenic mouse
  • Gene :

    PP2A Calpha mutant L199P

     
  • Line name :

    Dom1

     
  • Organ :

    Brain

     
  • Cell :

    Neurons

     
  • Feature :

    Expression of dominant negative mutant form of the catalytic subunit Calpha of Protein Phosphatase 2A (PP2A), L199P,
    under the control of the mThy1.2 promoter causes reduced PP2A activity and hyperphosphorylation of endogenous tau protein

     
  • Contact :

    Jürgen Götz

     
  • Email :

    goetzbli.unizh.ch

     
  • Phone :

    +411 634 8873

     
  • Lab :

    Division of Psychiatry Research

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:26

     


2. Targeted mouse
  • Gene :

    Pmp22

     
  • Line name :

    Trembler

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Tr NATURAL MUTANT mice. Asp to Gly point mutation in a putative membrane-associated domain of Pmp22 protein. The autosomal dominant trembler mutation (Tr) maps to mouse chromosome 11. Schwann-cell defect characterized by severe hypomyelination and continued Schwann-cell proliferation throughout life. Results in clumsy movement, tremor and transient seizures at young age.

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:33

     


3. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-TAP 929 and 932

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing TAP-tagged prion protein

     
  • Contact :

    Kirsten Mertz / Erich Brunner

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:47

     


4. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-myc 940 and 941

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing myc-tagged prion protein

     
  • Contact :

    Kirsten Mertz

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:48

     


5. Targeted mouse


6. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


7. Transgenic mouse
  • Gene :

    IL-12p35

     
  • Line name :

    B6;IL-12p35tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    The p35 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


8. Transgenic mouse
  • Gene :

    IL12p40

     
  • Line name :

    B6;IL-12p40tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    p40 has been shown to be a subunit of another composite cytokine, designated IL23 .
    The p40 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


9. Transgenic mouse


10. Transgenic mouse



All genes


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