NCCR


1. Transgenic mouse


2. Transgenic mouse


3. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-myc 940 and 941

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing myc-tagged prion protein

     
  • Contact :

    Kirsten Mertz

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:48

     


4. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-TAP 929 and 932

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing TAP-tagged prion protein

     
  • Contact :

    Kirsten Mertz / Erich Brunner

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:47

     


5. Transgenic mouse
  • Gene :

    PP2A Calpha mutant L199P

     
  • Line name :

    Dom1

     
  • Organ :

    Brain

     
  • Cell :

    Neurons

     
  • Feature :

    Expression of dominant negative mutant form of the catalytic subunit Calpha of Protein Phosphatase 2A (PP2A), L199P,
    under the control of the mThy1.2 promoter causes reduced PP2A activity and hyperphosphorylation of endogenous tau protein

     
  • Contact :

    Jürgen Götz

     
  • Email :

    goetzbli.unizh.ch

     
  • Phone :

    +411 634 8873

     
  • Lab :

    Division of Psychiatry Research

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:26

     


6. Targeted mouse
  • Gene :

    Pmp22

     
  • Line name :

    Trembler

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Tr NATURAL MUTANT mice. Asp to Gly point mutation in a putative membrane-associated domain of Pmp22 protein. The autosomal dominant trembler mutation (Tr) maps to mouse chromosome 11. Schwann-cell defect characterized by severe hypomyelination and continued Schwann-cell proliferation throughout life. Results in clumsy movement, tremor and transient seizures at young age.

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:33

     


7. Transgenic mouse


8. Transgenic mouse


9. Targeted mouse
  • Gene :

    MAG

     
  • Line name :

    MAG-KO

     
  • Organ :

    Nervous system

     
  • Cell :

    oligodendrocytes and Schwann cells

     
  • Feature :

    Knock-out for the myelin associated glycoprotein (MAG)

     
  • Contact :

    Leda Dimou

     
  • Email :

    dimouhifo.unizh.ch

     
  • Phone :

    +41 44 635 3256

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Wednesday, 6th July 2005 - 12:28

     


10. Transgenic mouse
  • Gene :

    Inhibitor-1 (PP1 inhibitor)

     
  • Line name :

    I-1*

     
  • Organ :

    Depends on the line of transactivator (tTA or rtTA) used for crossing

     
  • Cell :

    Forebrain neurons when crossed with CaMKIIα promoter-rtTA mice

     
  • Feature :

    TetO promoter fused to a constitutively active protein phosphatase 1 (PP1) inhibitor cDNA.
    Improved learning and memory when expressed in forebrain neurons.

     
  • Contact :

    Isabelle Mansuy

     
  • Email :

    mansuyhifo.unizh.ch

     
  • Phone :

    +41 44 635 3360

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Abstract

     
  • Update :

    Monday, 23rd July 2007 - 15:28

     



All genes


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