NCCR


1. Targeted mouse


2. Targeted mouse


3. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


4. Targeted mouse


5. Targeted mouse


6. Transgenic mouse
  • Gene :

    FcR(gamma)

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav

     
  • Organ :

    Ubiquitous

     
  • Cell :

    macrophages, neutrophils, mast cells, basophils and NK cells

     
  • Feature :

    Fcer1g knockout mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors. The deleted gamma chain subunit is essential for cell surface expression of these molecules.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    eur j immunol (1994) 25(7): 2107-2110.

     
  • Update :

    Monday, 15th November 2004 - 16:36

     


7. Transgenic mouse
  • Gene :

    FcR(gamma),IgH

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav x B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    This mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors and they are unable to produce functional Ab's.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


8. Targeted mouse


9. Targeted mouse


10. Targeted mouse



All genes


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