NCCR


1. Zebrafish
  • Gene :

    nn

     
  • Line name :

    zh54

     
  • Organ :

    eye

     
  • Cell :

    unknown

     
  • Feature :

    synaptic transmission between photoreceptors and bipolar cells by ERG measurement

     
  • Contact :

    Stephan Neuhauss

     
  • Email :

    neuhausshifo.unizh.ch

     
  • Phone :

    +411 635 3288

     
  • Lab :

    Brain Research Institute

     
  • Ref. :

    Unpublished

     
  • Update :

    Wednesday, 12th March 2003 - 09:58

     


2. Transgenic mouse
  • Gene :

    FcR(gamma),IgH

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav x B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    This mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors and they are unable to produce functional Ab's.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


3. Transgenic mouse
  • Gene :

    Rag1

     
  • Line name :

    B6.129S7-Rag1tm1Mom/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    Homozygotes for targeted null mutations are devoid of mature B and T lymphocytes due to an inability to rearrange their immunoglobulin and T cell receptor genes. Mutants show severe combined immunodeficiency and susceptibility to infections.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


4. Transgenic mouse
  • Gene :

    FcR(gamma)

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav

     
  • Organ :

    Ubiquitous

     
  • Cell :

    macrophages, neutrophils, mast cells, basophils and NK cells

     
  • Feature :

    Fcer1g knockout mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors. The deleted gamma chain subunit is essential for cell surface expression of these molecules.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    eur j immunol (1994) 25(7): 2107-2110.

     
  • Update :

    Monday, 15th November 2004 - 16:36

     


5. Transgenic mouse
  • Gene :

    MOG-TcR

     
  • Line name :

    B6-Tg(MOG-TcR)xB6-MOGiCREtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    T cells,Oligodendrocytes

     
  • Feature :

    These mice express a MOG specific T cell receptor on a MOG -/- background.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:29

     


6. Transgenic mouse
  • Gene :

    IL-18R

     
  • Line name :

    B6-IL18Rtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18 receptor

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


7. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


8. Targeted mouse


9. Targeted mouse
  • Gene :

    ptger3

     
  • Line name :

    ptger3tm1sna; EP3 receptor knock-out

     
  • Organ :

    various

     
  • Cell :

    various

     
  • Feature :

    Mouse lacking the EP3 subtype of prostaglandin E2 receptors

     
  • Contact :

    Hanns Ulrich Zeilhofer

     
  • Email :

    zeilhoferpharma.unizh.ch

     
  • Phone :

    +41 44 6355912

     
  • Lab :

    Institute of Pharmacology and Toxicology

     
  • Ref. :

    Abstract

     
  • Update :

    Friday, 19th May 2006 - 16:23

     


10. Targeted mouse
  • Gene :

    ptger2

     
  • Line name :

    ptger2tm1sna; EP2 receptor knock-out

     
  • Organ :

    CNS, kidney etc

     
  • Cell :

    various cell types

     
  • Feature :

    Mouse lacking the EP2 subtype of prostaglandin E2 receptors

     
  • Contact :

    Hanns Ulrich Zeilhofer

     
  • Email :

    zeilhoferpharma.unizh.ch

     
  • Phone :

    +41 44 6355912

     
  • Lab :

    Institute of Pharmacology and Toxicology

     
  • Ref. :

    Abstract

     
  • Update :

    Friday, 19th May 2006 - 16:23

     



All genes


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