NCCR


1. Transgenic mouse
  • Gene :

    IL-12p35

     
  • Line name :

    B6;IL-12p35tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    The p35 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


2. Transgenic mouse
  • Gene :

    IL12p40

     
  • Line name :

    B6;IL-12p40tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    p40 has been shown to be a subunit of another composite cytokine, designated IL23 .
    The p40 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


3. Transgenic mouse
  • Gene :

    CD40

     
  • Line name :

    B6.129P2-Tnfrsf5tm1Kik/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    CD40 protein is expressed on all B-lymphocytes during various stages of development, activated T-cells and monocytes, follicular dendritic cells, thymic epithelial cells.

     
  • Feature :

    Germinal center centrocytes are prevented from undergoing cell death by apoptosis by activation through CD40 and antigen receptors.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:57

     


4. Transgenic mouse
  • Gene :

    MHCII

     
  • Line name :

    B6-IABbtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Ubiquitous

     
  • Feature :

    No MHCII

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:37

     


5. Transgenic mouse
  • Gene :

    CD11c-DTR

     
  • Line name :

    B6-Tg(CD11c-DTR-eGFP)

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Dendritic cells

     
  • Feature :

    Inducible depletion of DC with diphtheria toxin

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:23

     


6. Transgenic mouse
  • Gene :

    CD11c-MHII

     
  • Line name :

    B6-Tg(CD11c-IABb)xB6-IABbtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Dendritic cells

     
  • Feature :

    Selective expression of the MHCII complex on DC in a MHCII -/- background

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:02

     


7. Transgenic mouse
  • Gene :

    IL-18R

     
  • Line name :

    B6-IL18Rtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18 receptor

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


8. Transgenic mouse
  • Gene :

    IL-18

     
  • Line name :

    B6-IL18tm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


9. Transgenic mouse
  • Gene :

    NIK

     
  • Line name :

    B6.AEj-Aly

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Ubiquitous

     
  • Feature :

    Alymphoplasie

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:13

     


10. Transgenic mouse
  • Gene :

    CRE

     
  • Line name :

    B6-MOGiCREtm

     
  • Organ :

    CNS

     
  • Cell :

    Oligodendrocytes

     
  • Feature :

    Cre line for recombination of loxP sites exclusively in MOG expressing cells.
    The MOG-gene is deleted.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     



All genes


!!! Dieses Dokument stammt aus dem ETH Web-Archiv und wird nicht mehr gepflegt !!!
!!! This document is stored in the ETH Web archive and is no longer maintained !!!