NCCR


1. Transgenic mouse
  • Gene :

    Rag1

     
  • Line name :

    B6.129S7-Rag1tm1Mom/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    Homozygotes for targeted null mutations are devoid of mature B and T lymphocytes due to an inability to rearrange their immunoglobulin and T cell receptor genes. Mutants show severe combined immunodeficiency and susceptibility to infections.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


2. Transgenic mouse
  • Gene :

    NIK

     
  • Line name :

    B6.AEj-Aly

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Ubiquitous

     
  • Feature :

    Alymphoplasie

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:13

     


3. Transgenic mouse
  • Gene :

    MOG-TcR

     
  • Line name :

    B6-Tg(MOG-TcR)xB6-MOGiCREtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    T cells,Oligodendrocytes

     
  • Feature :

    These mice express a MOG specific T cell receptor on a MOG -/- background.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:29

     


4. Transgenic mouse
  • Gene :

    MHCII

     
  • Line name :

    B6-IABbtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Ubiquitous

     
  • Feature :

    No MHCII

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 15:37

     


5. Transgenic mouse
  • Gene :

    IL12p40

     
  • Line name :

    B6;IL-12p40tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    p40 has been shown to be a subunit of another composite cytokine, designated IL23 .
    The p40 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


6. Transgenic mouse
  • Gene :

    IL-22 (IL-TIF)

     
  • Line name :

    B6-IL22tm

     
  • Organ :

    IL-TIF is expressed constitutively in thymus and brain.

     
  • Cell :

    thymic lymphomas, T-cells, and mast cells, and in freshly isolated splenocytes

     
  • Feature :

    No IL-22

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


7. Transgenic mouse
  • Gene :

    IL-18R

     
  • Line name :

    B6-IL18Rtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18 receptor

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


8. Transgenic mouse
  • Gene :

    IL-18

     
  • Line name :

    B6-IL18tm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


9. Transgenic mouse
  • Gene :

    IL-12p35

     
  • Line name :

    B6;IL-12p35tm/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    The IL-12 is a heterodimeric 70 kDa glycoprotein (IL12-p70 ) consisting of a 40 kDa subunit and a 35 kDa subunit.
    The p35 supunit is knock-out.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


10. Transgenic mouse
  • Gene :

    IgH

     
  • Line name :

    B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    No functional Ab's

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     



All genes


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