NCCR


1. Transgenic mouse
  • Gene :

    FcR(gamma),IgH

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav x B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    This mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors and they are unable to produce functional Ab's.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


2. Transgenic mouse
  • Gene :

    Rag1

     
  • Line name :

    B6.129S7-Rag1tm1Mom/J

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B and T cells

     
  • Feature :

    Homozygotes for targeted null mutations are devoid of mature B and T lymphocytes due to an inability to rearrange their immunoglobulin and T cell receptor genes. Mutants show severe combined immunodeficiency and susceptibility to infections.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


3. Transgenic mouse
  • Gene :

    IgH

     
  • Line name :

    B6-IgHtm1Mom

     
  • Organ :

    Ubiquitous

     
  • Cell :

    B cells

     
  • Feature :

    No functional Ab's

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


4. Transgenic mouse
  • Gene :

    IL-22 (IL-TIF)

     
  • Line name :

    B6-IL22tm

     
  • Organ :

    IL-TIF is expressed constitutively in thymus and brain.

     
  • Cell :

    thymic lymphomas, T-cells, and mast cells, and in freshly isolated splenocytes

     
  • Feature :

    No IL-22

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


5. Transgenic mouse
  • Gene :

    FcR(gamma)

     
  • Line name :

    B6.129P2-Fcerg1tm1Rav

     
  • Organ :

    Ubiquitous

     
  • Cell :

    macrophages, neutrophils, mast cells, basophils and NK cells

     
  • Feature :

    Fcer1g knockout mice are deficient in the gamma chain subunit of the FcgammaRI, FcgammaRIII and FcepsilonRI receptors. The deleted gamma chain subunit is essential for cell surface expression of these molecules.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    eur j immunol (1994) 25(7): 2107-2110.

     
  • Update :

    Monday, 15th November 2004 - 16:36

     


6. Transgenic mouse
  • Gene :

    MOG-TcR

     
  • Line name :

    B6-Tg(MOG-TcR)xB6-MOGiCREtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    T cells,Oligodendrocytes

     
  • Feature :

    These mice express a MOG specific T cell receptor on a MOG -/- background.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:29

     


7. Transgenic mouse
  • Gene :

    CRE

     
  • Line name :

    B6-MOGiCREtm

     
  • Organ :

    CNS

     
  • Cell :

    Oligodendrocytes

     
  • Feature :

    Cre line for recombination of loxP sites exclusively in MOG expressing cells.
    The MOG-gene is deleted.

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 17:07

     


8. Transgenic mouse
  • Gene :

    NIK

     
  • Line name :

    B6.AEj-Aly

     
  • Organ :

    Ubiquitous

     
  • Cell :

    Ubiquitous

     
  • Feature :

    Alymphoplasie

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:13

     


9. Transgenic mouse
  • Gene :

    IL-18

     
  • Line name :

    B6-IL18tm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     


10. Transgenic mouse
  • Gene :

    IL-18R

     
  • Line name :

    B6-IL18Rtm

     
  • Organ :

    Ubiquitous

     
  • Cell :

    monocytes and macrophages produce large amounts of various IL18 species

     
  • Feature :

    This mouse is unable to express IL-18 receptor

     
  • Contact :

    Burkhard Becher

     
  • Email :

    burkhard.becherusz.ch

     
  • Phone :

    +411 255 8842

     
  • Lab :

    Neuroimmunology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 15th November 2004 - 16:40

     



All genes


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