NCCR


1. Targeted mouse
  • Gene :

    3D-/-

     
  • Line name :

    3D-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    point mutation inactivating the 3D gene; see also Tabeta K, et al., 2006 Feb. Nat Immunol.

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. For neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 8th May 2006 - 12:14

     


2. Transgenic mouse
  • Gene :

    human prion gene polymorphism 129 M

     
  • Line name :

    129MM tg 35

     
  • Organ :

    CNS, stroma and lymphoid tissue

     
  • Cell :

    virtually on all cells that have an active prion promoter

     
  • Feature :

    expression of the human prion protein with M on position 129; mice are homozygous for the transgene, high expression in the CNS less in the lymphoid tissue;

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 8th May 2006 - 12:10

     


3. Targeted mouse
  • Gene :

    prnp

     
  • Line name :

    B6-PrnptmNgsk

     
  • Organ :

    prnp knockout but DpL overexpression

     
  • Cell :

    prnp knockout but Dpl overexpression

     
  • Feature :

    prnp knockout on C57BL/6 background; cerebellar granular degeneration (Dpl overexpression)

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 11th July 2005 - 18:09

     


4. Targeted mouse
  • Gene :

    prnp

     
  • Line name :

    Balb/c-PrnpZH1/ZH1

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    complete knockout on Balb/c background

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 11th July 2005 - 18:06

     


5. Transgenic mouse
  • Gene :

    N-terminal deletion of prnp

     
  • Line name :

    E1931 - B6,129Sv-Tg(delE)1931,PrnpZH1/ZH1

     
  • Organ :

    brain and periphery

     
  • Cell :

    brain and periphery

     
  • Feature :

    N-terminal deletion of prnp (on Prnp background) introduction of constuct pPrPN-term: (sequence encoding AA 68-83 was deleted)

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 11th July 2005 - 18:04

     


6. Transgenic mouse


7. Transgenic mouse


8. Targeted mouse


9. Transgenic mouse


10. Transgenic mouse



All genes


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