NCCR


1. Targeted mouse
  • Gene :

    C-gamma and RAG2

     
  • Line name :

    Cgamma -/- RAG2-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells as well as no NK cells on Balb/C and C57BL/10 backgound

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    traggiai et al., 2003 science

     
  • Update :

    Monday, 4th July 2005 - 17:53

     


2. Targeted mouse
  • Gene :

    CCR7 chemokine receptor for SDF-alpha

     
  • Line name :

    CCR7-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    mice lack DCs in lymphoid follicles; abberrant microarchitecture; DCs and Langerhans cells cannot not home into lymphoid organs

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. For neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 16:52

     


3. Targeted mouse


4. Targeted mouse
  • Gene :

    CD21 and prnp

     
  • Line name :

    CD21-/- prnp-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    kncokout for CD21 and prnp

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:37

     


5. Targeted mouse
  • Gene :

    CD40L receptor

     
  • Line name :

    CD40-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of CD40 signalling; nogerminal centers, no germinal center B-cells;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:12

     


6. Targeted mouse


7. Transgenic mouse
  • Gene :

    Cre-recombinase

     
  • Line name :

    Alb-Cre

     
  • Organ :

    liver

     
  • Cell :

    hepatocytes

     
  • Feature :

    active Cre rekombinase under the Alb-promoter

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:51

     


8. Targeted mouse


9. Targeted mouse


10. Targeted mouse
  • Gene :

    Interleukin 10

     
  • Line name :

    IL10-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of IL10 expression; CD like inflammation in the gut

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:05

     



All genes


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