NCCR


1. Transgenic mouse
  • Gene :

    Lymphotoxin alpha and Lymphotoxin beta

     
  • Line name :

    lck-LTa/b

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:57

     


2. Transgenic mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    lck-LTa

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:58

     


3. Transgenic mouse


4. Targeted mouse
  • Gene :

    Trif

     
  • Line name :

    Trif-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of Trif signalling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:06

     


5. Targeted mouse
  • Gene :

    TNFR2

     
  • Line name :

    TNFR2-/-

     
  • Organ :

    complete kncokout

     
  • Cell :

    complete knockout

     
  • Feature :

    no TNFR2 signalling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:10

     


6. Targeted mouse
  • Gene :

    CD40L receptor

     
  • Line name :

    CD40-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of CD40 signalling; nogerminal centers, no germinal center B-cells;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:12

     


7. Targeted mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    LTa-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no FDCs; defects in lymphoid moicroarchitecture;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:16

     


8. Targeted mouse
  • Gene :

    Lymphotoxin beta

     
  • Line name :

    LTb-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no FDCs; defects in lymphoid moicroarchitecture; no ILNs, no developped MLNs, few PPs;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:19

     


9. Targeted mouse
  • Gene :

    TNFR1

     
  • Line name :

    TNFR1-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    deficient TNFR1 signalling;
    disorganized lymphoid microarchitecture; no mature FDCs

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    rothe j. et al. nature (1993)

     
  • Update :

    Monday, 4th July 2005 - 14:24

     


10. Transgenic mouse



All genes


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