NCCR


21. Transgenic mouse
  • Gene :

    v-src oncogene

     
  • Line name :

    GFAP v-src

     
  • Organ :

    brain

     
  • Cell :

    brain

     
  • Feature :

    expression of v-src under the GFAP promoter

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:22

     


22. Targeted mouse
  • Gene :

    RAG1 and prnp

     
  • Line name :

    RAG1-/-prnp-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells no murine PrP expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:26

     


23. Targeted mouse
  • Gene :

    CCR7 chemokine receptor for SDF-alpha

     
  • Line name :

    CCR7-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    mice lack DCs in lymphoid follicles; abberrant microarchitecture; DCs and Langerhans cells cannot not home into lymphoid organs

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. For neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 16:52

     


24. Targeted mouse
  • Gene :

    RAG1

     
  • Line name :

    RAG1-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of RAG1; no B and T cells

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 17:04

     


25. Transgenic mouse
  • Gene :

    prnp gene

     
  • Line name :

    TgN 306 B6, 129Sv-TgN306(IgK), PRNPZH1/ZH1)

     
  • Organ :

    lymphoid organs

     
  • Cell :

    B-cell specific

     
  • Feature :

    B-cell specific expression of PrP on a prnp knockout background (Expression vector pHT4-YK 12 under the control of the Igk promoter)

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    montrasio et al. pnas 2001

     
  • Update :

    Monday, 4th July 2005 - 17:34

     


26. Transgenic mouse
  • Gene :

    prnp gene

     
  • Line name :

    TgN 431 B6, 12Sv-TgN431()CD19) PrnpZH1/ZH1

     
  • Organ :

    lymphoid organs

     
  • Cell :

    B-cells

     
  • Feature :

    B cell specific expression of the prion protein on a prnp knockout background

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    montrasio et al. pnas 2001

     
  • Update :

    Monday, 4th July 2005 - 17:34

     


27. Transgenic mouse


28. Targeted mouse
  • Gene :

    C-gamma and RAG2

     
  • Line name :

    Cgamma -/- RAG2-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells as well as no NK cells on Balb/C and C57BL/10 backgound

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    traggiai et al., 2003 science

     
  • Update :

    Monday, 4th July 2005 - 17:53

     



All genes


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