NCCR


11. Targeted mouse


12. Targeted mouse
  • Gene :

    CD21 and prnp

     
  • Line name :

    CD21-/- prnp-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    kncokout for CD21 and prnp

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:37

     


13. Targeted mouse


14. Targeted mouse
  • Gene :

    Interleukin 10

     
  • Line name :

    IL10-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of IL10 expression; CD like inflammation in the gut

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:05

     


15. Targeted mouse
  • Gene :

    C-gamma and RAG2

     
  • Line name :

    Cgamma -/- RAG2-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells as well as no NK cells on Balb/C and C57BL/10 backgound

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    traggiai et al., 2003 science

     
  • Update :

    Monday, 4th July 2005 - 17:53

     


16. Targeted mouse
  • Gene :

    RAG1 and prnp

     
  • Line name :

    RAG1-/-prnp-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells no murine PrP expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:26

     


17. Targeted mouse
  • Gene :

    CCR7 chemokine receptor for SDF-alpha

     
  • Line name :

    CCR7-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    mice lack DCs in lymphoid follicles; abberrant microarchitecture; DCs and Langerhans cells cannot not home into lymphoid organs

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. For neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 16:52

     


18. Targeted mouse
  • Gene :

    RAG1

     
  • Line name :

    RAG1-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of RAG1; no B and T cells

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 17:04

     


19. Transgenic mouse
  • Gene :

    Lymphotoxin alpha and Lymphotoxin beta

     
  • Line name :

    lck-LTa/b

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:57

     


20. Transgenic mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    lck-LTa

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:58

     



All genes


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