NCCR


1. Transgenic mouse
  • Gene :

    v-src oncogene

     
  • Line name :

    GFAP v-src

     
  • Organ :

    brain

     
  • Cell :

    brain

     
  • Feature :

    expression of v-src under the GFAP promoter

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:22

     


2. Targeted mouse
  • Gene :

    Trif

     
  • Line name :

    Trif-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of Trif signalling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:06

     


3. Targeted mouse
  • Gene :

    TNFR2

     
  • Line name :

    TNFR2-/-

     
  • Organ :

    complete kncokout

     
  • Cell :

    complete knockout

     
  • Feature :

    no TNFR2 signalling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:10

     


4. Targeted mouse
  • Gene :

    TNFR1

     
  • Line name :

    TNFR1-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    deficient TNFR1 signalling;
    disorganized lymphoid microarchitecture; no mature FDCs

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    rothe j. et al. nature (1993)

     
  • Update :

    Monday, 4th July 2005 - 14:24

     


5. Targeted mouse
  • Gene :

    Tlr9

     
  • Line name :

    Tlr9-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    resistant to CpG-ODN; defects in Tlr9 siganlling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:28

     


6. Targeted mouse
  • Gene :

    RAG1 and prnp

     
  • Line name :

    RAG1-/-prnp-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no B and T cells no murine PrP expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:26

     


7. Targeted mouse
  • Gene :

    RAG1

     
  • Line name :

    RAG1-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of RAG1; no B and T cells

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 17:04

     


8. Transgenic mouse
  • Gene :

    prnp gene

     
  • Line name :

    TgN 431 B6, 12Sv-TgN431()CD19) PrnpZH1/ZH1

     
  • Organ :

    lymphoid organs

     
  • Cell :

    B-cells

     
  • Feature :

    B cell specific expression of the prion protein on a prnp knockout background

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    montrasio et al. pnas 2001

     
  • Update :

    Monday, 4th July 2005 - 17:34

     


9. Transgenic mouse
  • Gene :

    prnp gene

     
  • Line name :

    TgN 306 B6, 129Sv-TgN306(IgK), PRNPZH1/ZH1)

     
  • Organ :

    lymphoid organs

     
  • Cell :

    B-cell specific

     
  • Feature :

    B-cell specific expression of PrP on a prnp knockout background (Expression vector pHT4-YK 12 under the control of the Igk promoter)

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    montrasio et al. pnas 2001

     
  • Update :

    Monday, 4th July 2005 - 17:34

     


10. Transgenic mouse



All genes


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