NCCR


11. Targeted mouse
  • Gene :

    MyD88

     
  • Line name :

    MyD88-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    defects in TLR siognalling

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:27

     


12. Transgenic mouse


13. Targeted mouse
  • Gene :

    Lymphotoxin beta

     
  • Line name :

    LTb-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no FDCs; defects in lymphoid moicroarchitecture; no ILNs, no developped MLNs, few PPs;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:19

     


14. Transgenic mouse
  • Gene :

    Lymphotoxin alpha and Lymphotoxin beta

     
  • Line name :

    lck-LTa/b

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:57

     


15. Transgenic mouse


16. Transgenic mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    lck-LTa

     
  • Organ :

    thymus rudiment , spleen, mln, iln

     
  • Cell :

    T-cell specific

     
  • Feature :

    accelerated thymic involution; ectopic FDC-M1+ cells in the T-cell zone, enlarged MLN and increased chemokine expression

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 13:58

     


17. Targeted mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    LTa-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    no FDCs; defects in lymphoid moicroarchitecture;

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:16

     


18. Transgenic mouse
  • Gene :

    Lymphotoxin alpha

     
  • Line name :

    RIP-LTa

     
  • Organ :

    pancreas and kidney

     
  • Cell :

    beta pancreatic cells and proximal tubules

     
  • Feature :

    ectopic tertiary follicles in pancreas and kidney

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 14:59

     


19. Targeted mouse
  • Gene :

    Interleukin 10

     
  • Line name :

    IL10-/-

     
  • Organ :

    complete knockout

     
  • Cell :

    complete knockout

     
  • Feature :

    lack of IL10 expression; CD like inflammation in the gut

     
  • Contact :

    Mathias Heikenwälder / Adriano Aguzzi

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th July 2005 - 15:05

     


20. Targeted mouse



All genes


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