NCCR


31. Targeted mouse
  • Gene :

    Pmp22

     
  • Line name :

    Trembler

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Tr NATURAL MUTANT mice. Asp to Gly point mutation in a putative membrane-associated domain of Pmp22 protein. The autosomal dominant trembler mutation (Tr) maps to mouse chromosome 11. Schwann-cell defect characterized by severe hypomyelination and continued Schwann-cell proliferation throughout life. Results in clumsy movement, tremor and transient seizures at young age.

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:33

     


32. Targeted mouse


33. Targeted mouse


34. Targeted mouse


35. Targeted mouse
  • Gene :

    prnp

     
  • Line name :

    B6-PrnptmNgsk

     
  • Organ :

    prnp knockout but DpL overexpression

     
  • Cell :

    prnp knockout but Dpl overexpression

     
  • Feature :

    prnp knockout on C57BL/6 background; cerebellar granular degeneration (Dpl overexpression)

     
  • Contact :

    Mathias Heikenwälder

     
  • Email :

    mathias.heikenwaelderusz.ch

     
  • Phone :

    +41 44 255 21 06

     
  • Lab :

    Inst. for Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 11th July 2005 - 18:09

     


36. Targeted mouse


37. Targeted mouse


38. Targeted mouse
  • Gene :

    ptger2

     
  • Line name :

    ptger2tm1sna; EP2 receptor knock-out

     
  • Organ :

    CNS, kidney etc

     
  • Cell :

    various cell types

     
  • Feature :

    Mouse lacking the EP2 subtype of prostaglandin E2 receptors

     
  • Contact :

    Hanns Ulrich Zeilhofer

     
  • Email :

    zeilhoferpharma.unizh.ch

     
  • Phone :

    +41 44 6355912

     
  • Lab :

    Institute of Pharmacology and Toxicology

     
  • Ref. :

    Abstract

     
  • Update :

    Friday, 19th May 2006 - 16:23

     


39. Targeted mouse
  • Gene :

    ptger3

     
  • Line name :

    ptger3tm1sna; EP3 receptor knock-out

     
  • Organ :

    various

     
  • Cell :

    various

     
  • Feature :

    Mouse lacking the EP3 subtype of prostaglandin E2 receptors

     
  • Contact :

    Hanns Ulrich Zeilhofer

     
  • Email :

    zeilhoferpharma.unizh.ch

     
  • Phone :

    +41 44 6355912

     
  • Lab :

    Institute of Pharmacology and Toxicology

     
  • Ref. :

    Abstract

     
  • Update :

    Friday, 19th May 2006 - 16:23

     


40. Targeted mouse



All genes


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