NCCR


1. Targeted mouse


2. Targeted mouse


3. Targeted mouse


4. Targeted mouse


5. Targeted mouse


6. Targeted mouse


7. Targeted mouse
  • Gene :

    Pmp22

     
  • Line name :

    Pmp22 KO

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Retarded onset of myelination, abundant sausage-like hypermyelination structures (tomacula) at a young age followed by severe demyelination, axonal loss and functional impairment. Mice carrying one functional copy of Pmp22 are less affected but also exhibit focal tomacula comparable morphologically to those in hereditary neuropathy with liability to pressure palsies (HNPP).

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Wednesday, 30th April 2003 - 11:21

     


8. Targeted mouse
  • Gene :

    Pmp22

     
  • Line name :

    Trembler

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Tr NATURAL MUTANT mice. Asp to Gly point mutation in a putative membrane-associated domain of Pmp22 protein. The autosomal dominant trembler mutation (Tr) maps to mouse chromosome 11. Schwann-cell defect characterized by severe hypomyelination and continued Schwann-cell proliferation throughout life. Results in clumsy movement, tremor and transient seizures at young age.

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:33

     


9. Targeted mouse
  • Gene :

    Sox10

     
  • Line name :

    Sox10-/+

     
  • Organ :

    Nervous system

     
  • Cell :

    Neural crest stem cells; oligodendrocytes

     
  • Feature :

    Targeted deletion of the transcription factor Sox10; lacZ knock in

     
  • Contact :

    Lukas Sommer

     
  • Email :

    sommercell.biol.ethz.ch

     
  • Phone :

    +411 633 3349

     
  • Lab :

    Institute of Cell Biology, ETHZ

     
  • Ref. :

    Unpublished

     
  • Update :

    Wednesday, 30th April 2003 - 11:43

     


10. Targeted mouse



All genes


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