NCCR


1. Transgenic mouse


2. Transgenic mouse


3. Transgenic mouse


4. Transgenic mouse


5. Transgenic mouse


6. Transgenic mouse
  • Gene :

    Pmp22

     
  • Line name :

    Pmp22 Tg

     
  • Organ :

    PNS

     
  • Cell :

    Schwann cell

     
  • Feature :

    Mice carrying 16-30 copies of the pmp22 gene have severe congenital hypomyelinating neuropathy with an almost complete lack of myelin and marked slowing of nerve conduction. Affected nerves have more nonmyelinating Schwann cells not forming onion bulbs but aligning in association with axons. Mutant Schwann cells adopt a premyelination-like state (express embryonic markers). Continued Schwann cell proliferation into adulthood.

     
  • Contact :

    Guya Giambonini-Brugnoli

     
  • Email :

    guya.brugnolicell.biol.ethz.ch

     
  • Phone :

    +411 633 3348

     
  • Lab :

    Institute of Cell Biology

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:26

     


7. Transgenic mouse
  • Gene :

    PP2A Calpha mutant L199P

     
  • Line name :

    Dom1

     
  • Organ :

    Brain

     
  • Cell :

    Neurons

     
  • Feature :

    Expression of dominant negative mutant form of the catalytic subunit Calpha of Protein Phosphatase 2A (PP2A), L199P,
    under the control of the mThy1.2 promoter causes reduced PP2A activity and hyperphosphorylation of endogenous tau protein

     
  • Contact :

    Jürgen Götz

     
  • Email :

    goetzbli.unizh.ch

     
  • Phone :

    +411 634 8873

     
  • Lab :

    Division of Psychiatry Research

     
  • Ref. :

    Abstract

     
  • Update :

    Sunday, 11th May 2003 - 10:26

     


8. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-TAP 929 and 932

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing TAP-tagged prion protein

     
  • Contact :

    Kirsten Mertz / Erich Brunner

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:47

     


9. Transgenic mouse
  • Gene :

    Prnp

     
  • Line name :

    PrP-myc 940 and 941

     
  • Organ :

    ubiquitous

     
  • Cell :

    Cells that express PrP (neurons)

     
  • Feature :

    Transgenic mice expressing myc-tagged prion protein

     
  • Contact :

    Kirsten Mertz

     
  • Email :

    kirsten.mertzusz.ch

     
  • Phone :

    +411 255 4092

     
  • Lab :

    Neuropathology

     
  • Ref. :

    Unpublished

     
  • Update :

    Monday, 4th August 2003 - 12:48

     


10. Transgenic mouse
  • Gene :

    Neurotrophin

     
  • Line name :

    K14NGF

     
  • Organ :

    Epidermis and lymphoid organs

     
  • Cell :

    Keratinocytes

     
  • Feature :

    Overexpression of NGF in the skin causes hypertrophy of sensory nerves in skin and sympathetic nerves in lymphoid organs

     
  • Contact :

    Markus Glatzel

     
  • Email :

    markus.glatzelusz.ch

     
  • Phone :

    +411 255 2849

     
  • Lab :

    Institute of Neuropathology

     
  • Ref. :

    j neurosci. 1994 mar;14(3 pt 2):1422-32.

     
  • Update :

    Tuesday, 5th August 2003 - 15:47

     



All genes


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